1y4z B 2.0 BS05 HEM C 1 I88 W220 R221 I88 W220 R221 1.7.5.1 0005515,0005886,0008940,0009055,0009061,0009325,0016020,0016491,0019645,0042126,0042128,0044799,0046872,0051538,0051539,0160182 P11349 15615728 806 MKIRSQVGMVLNLDKCIGCHTCSVTAKNVWTSREGVEYAWFNNVETKPGQGFPTDWENQEKYKGGWIRKINGKLQPRMGNRAMLLGKIFANPHLPGIDDYYEPFDFDYQNLHTAPEGSKSQPIARPRSLITGERMAKIEKGPNWEDDLGGEFDKLAKDKNFDNIQKAMYSQFENTFMMYLPRLCEHCLNPACVATCPSGAIYKREEDGIVLIDQDKCRGWRMCITGCPYKKIYFNWKSGKSEKCIFCYPRIEAGQPTVCSETCVGRIRYLGVLLYDADAIERAASTENEKDLYQRQLDVFLDPNDPKVIEQAIKDGIPLSVIEAAQQSPVYKMAMEWKLALPLHPEYRTLPMVWYVPPLSPIQSAADAGELGSNGILPDVESLRIPVQYLANLLTAGDTKPVLRALKRMLAMRHYKRAETVDGKVDTRALEEVGLTEAQAQEMYRYLAIANYEDRFVVPSSHRELAREAFPEKNGCGFTFGDGCHGSDTKFNLFNSRRIDAIDVTSKTE 1y4z C 2.0 BS01 HEM C 1 S39 S40 Q41 M48 F55 H56 R112 R202 H205 I206 S39 S40 Q41 M48 F55 H56 R104 R194 H197 I198 1.7.5.1 0005886,0008940,0009055,0009061,0009325,0016020,0016491,0019645,0020037,0042126,0042128,0044799,0046872,0160182 P11350 15615728 806 MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNLASNLFHIGILGIFVGHFFGMLTLPIEVKQKMAMFAGGASGVLCLIGGVLLLKRRLFSPRVRATTTGADILILSLLVIQCALGLLTIPFSAQHMDGSEMMKLVGWAQSVVTFHGGASQHLDGVAFIFRLHLVLGMTLFLLFPFSRLIHIWSVPVEYLTRKYQLVRARH 1y4z C 2.0 BS02 HEM C 2 I59 I62 H66 M70 A90 Q136 C137 G140 I144 M156 L159 H187 L188 G191 F195 I59 I62 H66 M70 A82 Q128 C129 G132 I136 M148 L151 H179 L180 G183 F187 1.7.5.1 0005886,0008940,0009055,0009061,0009325,0016020,0016491,0019645,0020037,0042126,0042128,0044799,0046872,0160182 P11350 15615728 807 MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNLASNLFHIGILGIFVGHFFGMLTLPIEVKQKMAMFAGGASGVLCLIGGVLLLKRRLFSPRVRATTTGADILILSLLVIQCALGLLTIPFSAQHMDGSEMMKLVGWAQSVVTFHGGASQHLDGVAFIFRLHLVLGMTLFLLFPFSRLIHIWSVPVEYLTRKYQLVRARH 1y4z C 2.0 BS03 PCI C 1 G65 H66 G69 K86 A90 M156 G65 H66 G69 K78 A82 M148 1.7.5.1 0005886,0008940,0009055,0009061,0009325,0016020,0016491,0019645,0020037,0042126,0042128,0044799,0046872,0160182 Ki=57nM -logKd/Ki=7.24, Ki=57nM P11350 15615728 1808 MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNLASNLFHIGILGIFVGHFFGMLTLPIEVKQKMAMFAGGASGVLCLIGGVLLLKRRLFSPRVRATTTGADILILSLLVIQCALGLLTIPFSAQHMDGSEMMKLVGWAQSVVTFHGGASQHLDGVAFIFRLHLVLGMTLFLLFPFSRLIHIWSVPVEYLTRKYQLVRARH