6ob0 A 2.81 BS04 M3D B 1 F415 W417 F386 W388 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 -logKd/Ki=4.96, Kd~11uM P06858 31072929 503 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 A 2.81 BS05 M3D B 2 W420 W421 W391 W392 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 -logKd/Ki=4.96, Kd~11uM P06858 31072929 504 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 B 2.81 BS01 M3D A 1 F415 W417 F386 W388 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 P06858 31072929 503 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 B 2.81 BS02 M3D A 2 W420 W421 W391 W392 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 P06858 31072929 504 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 B 2.81 BS03 M3D B 1 W82 L263 V264 K265 W53 L234 V235 K236 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 P06858 31072929 503 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 B 2.81 BS04 M3D B 2 W82 Y121 P122 S159 K265 H268 W53 Y92 P93 S130 K236 H239 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 P06858 31072929 504 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN 6ob0 B 2.81 BS05 CA B 1 A194 R197 L198 S199 D202 A165 R168 L169 S170 D173 W82 S159 L160 D183 H268 W53 S130 L131 D154 H239 3.1.1.32,3.1.1.34 0004465,0004620,0004806,0005102,0005509,0005515,0005576,0005615,0005886,0006629,0006631,0006633,0006641,0006644,0008201,0008970,0009617,0009749,0009986,0010744,0010884,0010886,0010890,0016042,0016298,0016787,0019433,0031670,0032722,0032731,0032755,0032760,0034185,0034361,0034371,0034372,0034375,0042627,0042632,0042803,0043395,0043495,0045600,0046872,0050729,0052689,0052739,0052740,0055096,0070328,0071398,0071813,1902494,1904179,2000343 P06858 31072929 508 QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLN