5qij A 2.65 BS03 HJG B 1 L171 Q177 D259 S261 L147 Q153 D235 S237 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 IC50=600nM, Ki=380nM P50172 30613321 301 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 5qij A 2.65 BS04 HJG B 3 M276 F279 S280 Y283 M252 F255 S256 Y259 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 IC50=600nM, Ki=380nM P50172 30613321 304 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 5qij B 2.65 BS01 HJG B 1 M276 F279 S280 Y283 M252 F255 S256 Y259 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 IC50=600nM, Ki=380nM P50172 30613321 301 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 5qij B 2.65 BS02 NAP B 1 G41 S43 G45 I46 R66 S67 T92 M93 N119 H120 I121 I168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G17 S19 G21 I22 R42 S43 T68 M69 N95 H96 I97 I144 S146 Y159 K163 L191 G192 L193 I194 T196 T198 A199 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 P50172 30613321 302 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 5qij B 2.65 BS03 HJG B 2 T124 S125 L126 L171 A172 I180 Y183 L217 A223 E226 T100 S101 L102 L147 A148 I156 Y159 L193 A199 E202 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 IC50=600nM, Ki=380nM P50172 30613321 303 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF 5qij B 2.65 BS04 HJG B 3 L171 Q177 D259 S261 L267 L147 Q153 D235 S237 L243 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005783,0005789,0008202,0016020,0016491,0030324,0042803,0047022,0050661,0070524 IC50=600nM, Ki=380nM P50172 30613321 304 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMF