5hez B 2.66 BS01 1M3 B 1 F1019 W1020 Y1021 L1026 W1038 L1078 L1081 F178 W179 Y180 L185 W197 L237 L240 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS02 1M3 B 2 L855 G856 V863 A880 L932 G935 L983 D994 L14 G15 V22 A39 L91 G94 L142 D153 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1203 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS03 ZN B 1 H886 H891 H45 H50 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 O60674 27807284 1204 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS04 1M3 D 1 L1082 K1083 L241 K242 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez C 2.66 BS02 ZN B 1 H886 H891 H45 H50 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 O60674 27807284 1204 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez D 2.66 BS01 1M3 B 1 L1082 K1083 L241 K242 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG