5gvm A 2.24 BS03 PLG B 1 Y54 Y64 Y54 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvm A 2.24 BS04 G57 B 1 E56 Y63 E56 Y63 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=186nM -logKd/Ki=6.73, Kd=186nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvm B 2.24 BS01 PLG A 1 Y54 Y64 Y54 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvm B 2.24 BS02 G57 A 1 E56 Y63 E56 Y63 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=186nM -logKd/Ki=6.73, Kd=186nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvm B 2.24 BS03 PLG B 1 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvm B 2.24 BS04 G57 B 1 L124 G128 H129 T183 K355 N356 T357 P367 L124 G128 H129 T183 K355 N356 T357 P367 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=186nM -logKd/Ki=6.73, Kd=186nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP