5ek2 B 2.68 BS01 HEM B 1 F163 S167 V170 F214 F226 S263 A264 F270 F291 R343 H346 I349 V350 Y353 I354 L384 L388 V391 F152 S156 V159 F203 F215 S252 A253 F259 F280 R332 H335 I338 V339 Y342 I343 L359 L363 V366 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 P14902 26642377 501 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQEAKGTGGTDLMNFLKTVRSTTEKSLLKEG 5ek2 B 2.68 BS02 5PJ B 1 F163 F164 L234 G262 S263 A264 F152 F153 L223 G251 S252 A253 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 IC50=279nM, EC50=725nM P14902 26642377 502 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQEAKGTGGTDLMNFLKTVRSTTEKSLLKEG