4gtq B 2.6 BS01 ZN B 1 D297 C299 H362 D279 C281 H344 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H230 R273 K276 D279 C281 Y282 D334 D341 H344 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 22963166 501 WSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 4gtq B 2.6 BS02 FPP B 1 R202 H248 G250 Y251 R291 K294 Y300 W303 R184 H230 G232 Y233 R273 K276 Y282 W285 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H230 R273 K276 D279 C281 Y282 D334 D341 H344 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 22963166 502 WSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 4gtq B 2.6 BS03 7TQ B 1 L96 A98 S99 W102 A151 P152 D297 D359 Y361 H362 L78 A80 S81 W84 A133 P134 D279 D341 Y343 H344 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H230 R273 K276 D279 C281 Y282 D334 D341 H344 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 -logKd/Ki=8.30, IC50<5nM Q02293 22963166 503 WSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF