4g8l A 2.8 BS02 25A B 1 M306 R309 R310 Y312 M288 R291 R292 Y294 3.1.26.- -logKd/Ki=8.00, Kd=10nM IC50=20nM, EC50=0.210000nM Q05823 23084743 401 SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTCGDLVMTARRNYDHSLVKVLLSHGA 4g8l B 2.8 BS01 25A A 1 M306 R309 R310 Y312 M275 R278 R279 Y281 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA 4g8l B 2.8 BS02 25A B 1 E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155 E35 E37 G38 W40 Q48 K69 Y104 F106 E111 Y115 R135 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA