4fam B 2.0 BS01 NAP B 1 G22 Y24 D50 Y55 H117 N167 Q190 Y216 S217 L219 S221 Q222 A253 L268 K270 S271 Y272 R276 Q279 N280 G17 Y19 D45 Y50 H112 N162 Q185 Y211 S212 L214 S216 Q217 A248 L263 K265 S266 Y267 R271 Q274 N275 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 P42330 22877157 701 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPY 4fam B 2.0 BS02 0SZ B 1 L54 Y55 H117 N167 W227 F306 L49 Y50 H112 N162 W222 F301 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 ic50=0.013uM IC50=13nM P42330 22877157 702 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPY