3e37 B 1.8 BS01 GLC C 1 Q235 N236 W237 Q219 N220 W221 H250 R293 K296 D299 C301 Y302 D354 D361 H364 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 19246009 1 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 3e37 B 1.8 BS02 FRU C 1 Q235 N236 N271 S274 Q219 N220 N255 S258 H250 R293 K296 D299 C301 Y302 D354 D361 H364 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 19246009 2 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 3e37 B 1.8 BS03 ED5 B 1 W104 Y156 R204 Y207 G252 C256 D299 W305 D361 Y363 H364 W88 Y140 R188 Y191 G236 C240 D283 W289 D345 Y347 H348 H250 R293 K296 D299 C301 Y302 D354 D361 H364 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 ic50=4050nM -logKd/Ki=5.39, IC50=4.05uM P49356 19246009 1 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 3e37 B 1.8 BS04 ZN B 1 D299 C301 H364 D283 C285 H348 H250 R293 K296 D299 C301 Y302 D354 D361 H364 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 19246009 1001 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE