3da9 B 1.8 BS01 peptide A 0 E44 G46 M47 P49 W50 D149 H152 P153 C155 Y170 K171 R173 N194 M241 K242 N247 R248 W249 E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212 H79 D135 E232 G233 D234 S235 G236 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 P00734 19371038 7 ~ 33 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 3da9 B 1.8 BS02 peptide D 0 F55 R98 R104 T105 R106 Y107 K113 I114 F19 R62 R68 T69 R70 Y71 K77 I78 H79 D135 E232 G233 D234 S235 G236 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 P00734 19371038 355 ~ 363 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 3da9 B 1.8 BS03 44U B 1 Y83 N131 L132 I209 C231 S235 S256 W257 G258 E259 Y47 N95 L96 I172 C194 S198 S219 W220 G221 E222 H79 D135 E232 G233 D234 S235 G236 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 Kd=3.1uM -logKd/Ki=5.51, Kd=3.1uM Kd=3100nM, IC50=18000nM P00734 19371038 1 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG