2ziz A 2.2 BS03 NAD B 1 K489 Y493 K479 Y483 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz B 2.2 BS01 NAD A 1 K489 Y493 K479 Y483 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz B 2.2 BS02 AD3 B 1 H69 T71 D156 E218 T219 K248 D252 H363 H416 M421 H59 T61 D146 E208 T209 K238 D242 H353 H406 M411 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=20uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz B 2.2 BS03 NAD B 1 T219 T220 T221 N253 G284 V286 E305 I306 N310 T338 N340 I343 I361 G362 H363 N409 H416 T209 T210 T211 N243 G274 V276 E295 I296 N300 T328 N330 I333 I351 G352 H353 N399 H406 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 P9WGV3 18815415 550 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY