2wpf B 1.9 BS01 FAD B 1 I10 G11 G13 S14 G15 V34 D35 V36 A46 G50 T51 C52 V55 G56 C57 K60 W126 G127 T160 G161 F198 R287 R290 G326 D327 M333 L334 T335 I9 G10 G12 S13 G14 V33 D34 V35 A45 G49 T50 C51 V54 G55 C56 K59 W125 G126 T159 G160 F197 R286 R289 G325 D326 M332 L333 T334 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP 2wpf B 1.9 BS02 WPF B 1 S14 L17 E18 W21 Y110 M113 F114 I339 S13 L16 E17 W20 Y109 M112 F113 I338 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.23uM Q389T8 21851087 1000 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLP