2wp6 B 2.5 BS01 FAD B 1 G13 S14 G15 V34 D35 V36 A46 A47 G50 T51 C52 G56 C57 K60 G127 T160 I199 R287 R290 G326 D327 M333 L334 T335 G12 S13 G14 V33 D34 V35 A45 A46 G49 T50 C51 G55 C56 K59 G126 T159 I198 R286 R289 G325 D326 M332 L333 T334 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 Q389T8 21851087 998 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD 2wp6 B 2.5 BS02 WP6 B 1 S14 L17 E18 W21 G49 Y110 M113 F114 S13 L16 E17 W20 G48 Y109 M112 F113 S14 L48 C52 C57 K60 G85 S86 F198 E202 I339 G459 H461 E466 E485 K486 S13 L47 C51 C56 K59 G84 S85 F197 E201 I338 G458 H460 E465 E484 K485 1.8.1.12 0000166,0004791,0005654,0005737,0015036,0015042,0016491,0016668,0020015,0045454,0046872,0050660,0097014,0098869 ic50=0.93uM Q389T8 21851087 1000 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKLPD