2r2l B 2.23 BS01 ZN B 1 D297 C299 H362 D275 C277 H340 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H226 R269 K272 D275 C277 Y278 D330 D337 H340 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 17606674 1 LYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 2r2l B 2.23 BS02 FPP B 1 R202 H248 G250 Y251 C254 R291 K294 Y300 W303 R180 H226 G228 Y229 C232 R269 K272 Y278 W281 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H226 R269 K272 D275 C277 Y278 D330 D337 H340 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 Q02293 17606674 424 LYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 2r2l B 2.23 BS03 PB9 B 1 L96 S99 W102 W106 H149 D297 D359 Y361 H362 L74 S77 W80 W84 H127 D275 D337 Y339 H340 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H226 R269 K272 D275 C277 Y278 D330 D337 H340 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 ic50=0.58nM -logKd/Ki=9.00, IC50=1nM Q02293 17606674 425 LYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF