2kce A 2.2 BS03 UMP B 1 R126 R127 R126 R127 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 8939755 567 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 2kce B 2.2 BS01 UMP A 1 R126 R127 R126 R127 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 8939755 565 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 2kce B 2.2 BS02 UMP B 1 R21 C146 Q165 R166 S167 D169 N177 H207 Y209 R21 C146 Q165 R166 S167 D169 N177 H207 Y209 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 8939755 567 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 2kce B 2.2 BS03 D16 B 1 H51 S54 I79 W80 W83 D169 G173 F176 Y209 A263 H51 S54 I79 W80 W83 D169 G173 F176 Y209 A263 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 Ki=0.67uM -logKd/Ki=6.17, Ki=0.67uM IC50=2300nM P0A884 8939755 568 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI