1mmp B 2.3 BS01 ZN B 1 H218 H222 H228 H120 H124 H130 H218 E219 H222 H228 H120 E121 H124 H130 3.4.24.23 0004222,0006508,0008237,0008270,0031012 P09237 7756291 1 YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK 1mmp B 2.3 BS02 ZN B 2 H168 D170 H183 H196 H69 D71 H84 H97 H218 E219 H222 H228 H120 E121 H124 H130 3.4.24.23 0004222,0006508,0008237,0008270,0031012 P09237 7756291 2 YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK 1mmp B 2.3 BS03 CA B 1 D158 G190 G192 D194 D59 G91 G93 D95 H218 E219 H222 H228 H120 E121 H124 H130 3.4.24.23 0004222,0006508,0008237,0008270,0031012 P09237 7756291 3 YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK 1mmp B 2.3 BS04 CA B 2 D175 G176 G178 T180 D198 E201 D76 G77 G79 T81 D99 E102 H218 E219 H222 H228 H120 E121 H124 H130 3.4.24.23 0004222,0006508,0008237,0008270,0031012 P09237 7756291 4 YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK 1mmp B 2.3 BS05 RSS B 1 N179 L181 H218 E219 H228 P238 T239 Y240 N80 L82 H120 E121 H130 P140 T141 Y142 H218 E219 H222 H228 H120 E121 H124 H130 3.4.24.23 0004222,0006508,0008237,0008270,0031012 Ki=0.85uM -logKd/Ki=6.07, Ki=0.85uM Ki=850nM P09237 7756291 269 YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK