1ktt B 2.1 BS01 peptide A 0 E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207 E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212 H57 D102 E192 G193 D194 S195 G196 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 P00734 11960487 1C~ 14J IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 1ktt B 2.1 BS02 peptide C 0 F34 Q38 L40 R67 R73 T74 R75 Y76 I82 M84 F19 Q24 L26 R62 R68 T69 R70 Y71 I78 M80 H57 D102 E192 G193 D194 S195 G196 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 P00734 11960487 255 ~ 264 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 1ktt B 2.1 BS03 C02 B 1 H57 Y60A W60D E97A N98 L99 I174 D189 A190 V213 S214 W215 G216 G219 C220 H43 Y47 W50 E94 N95 L96 I172 D192 A193 V218 S219 W220 G221 G223 C224 H57 D102 E192 G193 D194 S195 G196 H43 D99 E195 G196 D197 S198 G199 3.4.21.5 0004252,0005509,0006508,0007596 ic50=1.5uM -logKd/Ki=5.82, IC50=1.5uM IC50=1500nM P00734 11960487 1 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE