1kbq B 1.8 BS01 FAD B 1 H11 S16 F17 N18 A20 P102 L103 Q104 W105 F106 T147 T148 G149 Y155 I192 R200 H9 S14 F15 N16 A18 P100 L101 Q102 W103 F104 T145 T146 G147 Y153 I190 R198 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 11735396 602 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq B 1.8 BS02 936 B 1 P68 Y126 Y128 F178 F232 F236 P66 Y124 Y126 F176 F230 F234 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 704 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq B 1.8 BS03 FAD D 1 Q66 P68 Q64 P66 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 11735396 604 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq B 1.8 BS04 936 D 1 W105 M154 H161 W103 M152 H159 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 702 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq D 1.8 BS01 FAD B 1 Q66 Y67 P68 Q65 Y66 P67 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 11735396 602 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq D 1.8 BS02 936 B 1 W105 G149 G150 M154 W104 G148 G149 M153 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 704 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK