1d7x B 2.0 BS01 ZN B 1 H701 H705 H711 H119 H123 H129 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10639284 801 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d7x B 2.0 BS02 ZN B 2 H651 D653 H666 H679 H69 D71 H84 H97 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10639284 802 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d7x B 2.0 BS03 CA B 1 D658 G659 G661 V663 D681 E684 D76 G77 G79 V81 D99 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10639284 803 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d7x B 2.0 BS04 CA B 2 D607 D682 E684 D25 D100 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10639284 804 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d7x B 2.0 BS05 CA B 3 D641 G673 N675 D677 D59 G91 N93 D95 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10639284 805 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d7x B 2.0 BS06 SPC B 1 V663 L664 A665 H701 E702 H705 H711 L722 Y723 V81 L82 A83 H119 E120 H123 H129 L140 Y141 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.52, IC50=3nM IC50=19nM P08254 10639284 901 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET