1ca8 B 2.1 BS01 peptide A 0 E23 I24 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207 E8 I9 G10 M11 P13 W14 D112 H115 P116 C118 Y133 K134 R136 N155 M202 K203 R209 W210 H57 D102 E192 G193 D194 S195 G196 H42 D98 E193 G194 D195 S196 G197 3.4.21.5 0004252,0005509,0006508,0007596 P00734 9724521 1B~ 14J IVEGSDAEIGMSPWQVMLFRKPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 1ca8 B 2.1 BS02 peptide C 0 F34 R67 R73 T74 R75 Y76 K81 I82 F19 R61 R67 T68 R69 Y70 K76 I77 H57 D102 E192 G193 D194 S195 G196 H42 D98 E193 G194 D195 S196 G197 3.4.21.5 0004252,0005509,0006508,0007596 P00734 9724521 56 ~ 63 IVEGSDAEIGMSPWQVMLFRKPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 1ca8 B 2.1 BS03 0KV B 1 H57 Y60A W60D I174 D189 C191 S195 S214 W215 G216 G219 H42 Y46 W49 I170 D190 C192 S196 S217 W218 G219 G221 H57 D102 E192 G193 D194 S195 G196 H42 D98 E193 G194 D195 S196 G197 3.4.21.5 0004252,0005509,0006508,0007596 -logKd/Ki=9.49, Ki=0.32nM IC50=0.67nM P00734 9724521 248 IVEGSDAEIGMSPWQVMLFRKPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG