8ico A 2.7 BS01 dna T 0 K230 G231 E232 T233 K234 Y296 K222 G223 E224 T225 K226 Y288 D190 D192 D256 D182 D184 D248 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 8841119 1 ~ 8 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 8ico A 2.7 BS02 dna P 0 G105 I106 G107 S109 A110 R254 G97 I98 G99 S101 A102 R246 D190 D192 D256 D182 D184 D248 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 8841119 1 ~ 7 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 8ico A 2.7 BS03 MN A 1 D190 D192 D182 D184 D190 D192 D256 D182 D184 D248 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 P06746 8841119 340 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 8ico A 2.7 BS04 AZT A 1 R149 S180 S188 G189 D190 Y271 F272 T273 G274 R141 S172 S180 G181 D182 Y263 F264 T265 G266 D190 D192 D256 D182 D184 D248 2.7.7.7,4.2.99.-,4.2.99.18 0001701,0003677,0003684,0003887,0003906,0005515,0005634,0005654,0005737,0005874,0005876,0006259,0006260,0006261,0006281,0006284,0006287,0006290,0006297,0006303,0006915,0006954,0006974,0007435,0008017,0008630,0010332,0016445,0016446,0016779,0016829,0019899,0032991,0034061,0045471,0046872,0048535,0048536,0048872,0051402,0051575,0055093,0071707,0071897,0140078 IC50=16000nM P06746 8841119 338 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE