6z9d A 1.9 BS01 ZN A 1 D36 H38 D85 D10 H12 D59 3.1.3.35,3.1.3.5,3.1.3.89,3.1.3.91,3.1.3.99 0000166,0002953,0005515,0005654,0005829,0005886,0006196,0006259,0007159,0008252,0008253,0008270,0009166,0009897,0009986,0010035,0016020,0016787,0016788,0033198,0042802,0046032,0046034,0046086,0046872,0050340,0050483,0050484,0050728,0055074,0070062,0098552,0106411,0110148,0140928 P21589 32614585 601 WELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 6z9d A 1.9 BS02 ZN A 2 D85 N117 H220 H243 D59 N91 H194 H217 3.1.3.35,3.1.3.5,3.1.3.89,3.1.3.91,3.1.3.99 0000166,0002953,0005515,0005654,0005829,0005886,0006196,0006259,0007159,0008252,0008253,0008270,0009166,0009897,0009986,0010035,0016020,0016787,0016788,0033198,0042802,0046032,0046034,0046086,0046872,0050340,0050483,0050484,0050728,0055074,0070062,0098552,0106411,0110148,0140928 P21589 32614585 602 WELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 6z9d A 1.9 BS03 CA A 1 N213 D237 G298 N187 D211 G272 3.1.3.35,3.1.3.5,3.1.3.89,3.1.3.91,3.1.3.99 0000166,0002953,0005515,0005654,0005829,0005886,0006196,0006259,0007159,0008252,0008253,0008270,0009166,0009897,0009986,0010035,0016020,0016787,0016788,0033198,0042802,0046032,0046034,0046086,0046872,0050340,0050483,0050484,0050728,0055074,0070062,0098552,0106411,0110148,0140928 P21589 32614585 603 WELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 6z9d A 1.9 BS04 QDH A 1 H38 D85 Q88 N117 H118 D121 L184 N186 H243 R354 N390 G392 R395 F417 G447 F500 D506 H12 D59 Q62 N91 H92 D95 L158 N160 H217 R328 N355 G357 R360 F382 G412 F465 D471 3.1.3.35,3.1.3.5,3.1.3.89,3.1.3.91,3.1.3.99 0000166,0002953,0005515,0005654,0005829,0005886,0006196,0006259,0007159,0008252,0008253,0008270,0009166,0009897,0009986,0010035,0016020,0016787,0016788,0033198,0042802,0046032,0046034,0046086,0046872,0050340,0050483,0050484,0050728,0055074,0070062,0098552,0106411,0110148,0140928 Ki=5pM Ki=0.005000nM P21589 32614585 604 WELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS