6npu A 2.33 BS01 STI A 1 L267 Y272 A288 K290 E305 M309 V318 T334 F336 M337 I379 H380 L389 A399 D400 F401 L17 Y22 A38 K40 E50 M54 V63 T79 F81 M82 I124 H125 L134 A144 D145 F146 D382 A384 R386 N387 D400 P421 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 IC50=38nM, Kd=44nM, Ki=13nM, EC50=7e+1nM P00519 30689376 601 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 6npu A 2.33 BS02 KWV A 1 A356 L359 L360 A452 Y454 E481 G482 P484 V487 A101 L104 L105 A197 Y199 E226 G227 P229 V232 D382 A384 R386 N387 D400 P421 D127 A129 R131 N132 D145 P166 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.00000001M -logKd/Ki=6.40, IC50=0.40uM IC50=398nM, EC50=794nM P00519 30689376 602 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES