6etj A 2.51 BS01 F6P A 1 H253 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 H241 I252 G253 E310 Y321 R335 K339 Y350 Q376 R380 R252 H253 N259 S302 E322 H387 R240 H241 N247 S290 E310 H375 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30250201 602 ELTQSRVQKIWVPVDHRPSLSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 6etj A 2.51 BS02 BWW A 1 V70 G71 R74 F87 M95 R98 A125 T126 N127 R132 Y193 V58 G59 R62 F75 M83 R86 A113 T114 N115 R120 Y181 R252 H253 N259 S302 E322 H387 R240 H241 N247 S290 E310 H375 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 -logKd/Ki=6.72, IC50=0.19uM Q16875 30250201 603 ELTQSRVQKIWVPVDHRPSLSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 6etj A 2.51 BS03 ADP A 1 A44 R45 G46 K47 T48 Y49 N163 E166 V167 K168 V217 Y424 A32 R33 G34 K35 T36 Y37 N151 E154 V155 K156 V205 Y412 R252 H253 N259 S302 E322 H387 R240 H241 N247 S290 E310 H375 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30250201 604 ELTQSRVQKIWVPVDHRPSLSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER