6esm A 1.104 BS01 ZN A 1 H226 H230 H236 H115 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 301 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS02 ZN A 2 H175 D177 H190 H203 H64 D66 H79 H92 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 302 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS03 CA A 1 D182 G183 D185 L187 D205 E208 D71 G72 D74 L76 D94 E97 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 303 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS04 CA A 2 D165 G197 Q199 D201 D54 G86 Q88 D90 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 304 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS05 CA A 3 D131 D206 E208 D20 D95 E97 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 305 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS06 B9Z A 1 G186 L187 A189 H226 Q227 H230 H236 L243 P246 M247 Y248 R249 G75 L76 A78 H115 Q116 H119 H125 L132 P135 M136 Y137 R138 3.4.24.35 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=5.53, IC50=2960nM IC50=2960nM P14780 29727184 306 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 6esm A 1.104 BS07 PZE A 1 Y179 A191 F192 Y68 A80 F81 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 29727184 307 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG