6ep4 A 2.30005 BS01 FUL B 1 L249 F278 V280 P281 L247 F276 V278 P279 G116 G117 G149 S198 A199 Y237 V288 F290 E325 H438 G114 G115 G147 S196 A197 Y235 V286 F288 E323 H432 3.1.1.8 0001540,0003824,0003990,0004104,0005515,0005576,0005615,0005641,0005783,0005788,0005886,0006581,0006805,0007584,0007612,0008285,0009410,0014016,0016486,0016788,0019695,0019899,0033265,0042802,0043279,0050783,0050805,0051384,0051593,0052689,0072562 P06276 29186056 3 DIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNPQETQNQSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV 6ep4 A 2.30005 BS02 DME A 1 W82 P285 Y332 H438 W80 P283 Y330 H432 G116 G117 G149 S198 A199 Y237 V288 F290 E325 H438 G114 G115 G147 S196 A197 Y235 V286 F288 E323 H432 3.1.1.8 0001540,0003824,0003990,0004104,0005515,0005576,0005615,0005641,0005783,0005788,0005886,0006581,0006805,0007584,0007612,0008285,0009410,0014016,0016486,0016788,0019695,0019899,0033265,0042802,0043279,0050783,0050805,0051384,0051593,0052689,0072562 Ki=4.5uM -logKd/Ki=5.35, Ki=4.5uM P06276 29186056 601 DIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNPQETQNQSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV