6e4w A 3.35 BS01 STU A 1 L22 G23 V24 G25 V30 A43 I77 M93 E94 Y95 V96 G99 E100 E143 N144 L146 D157 L14 G15 V16 G17 V22 A35 I69 M85 E86 Y87 V88 G91 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54645 30036059 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 6e4w A 3.35 BS02 HUG A 1 L18 G19 K31 I46 D88 L10 G11 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 -logKd/Ki=6.70, Kd=197.8nM P54645 30036059 602 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 6e4w B 3.35 BS01 HUG A 1 R83 S108 V113 R5 S30 V35 ? P80386 30036059 602 PTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKAPPILPPHLLQVILNKSCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI