5w49 A 2.4 BS01 NAD A 1 D190 N191 G222 D223 V224 E243 I244 N248 T276 I281 I299 G300 N346 D187 N188 G219 D220 V221 E240 I241 N245 T273 I278 I296 G297 N343 H55 S78 S83 D131 E156 N181 K186 D190 N191 C195 H301 H353 S361 Q365 H52 S75 S80 D128 E153 N178 K183 D187 N188 C192 H298 H350 S358 Q362 3.13.2.1 0004013,0005515,0005634,0005737,0005783,0005829,0006730,0016787,0033353,0042470,0070062 P23526 28533090 501 KLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY 5w49 A 2.4 BS02 9W1 A 1 H55 T57 E59 L347 H353 M358 H52 T54 E56 L344 H350 M355 H55 S78 S83 D131 E156 N181 K186 D190 N191 C195 H301 H353 S361 Q365 H52 S75 S80 D128 E153 N178 K183 D187 N188 C192 H298 H350 S358 Q362 3.13.2.1 0004013,0005515,0005634,0005737,0005783,0005829,0006730,0016787,0033353,0042470,0070062 ic50=8uM P23526 28533090 508 KLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY 5w49 A 2.4 BS03 NAD B 1 K426 Y430 K423 Y427 H55 S78 S83 D131 E156 N181 K186 D190 N191 C195 H301 H353 S361 Q365 H52 S75 S80 D128 E153 N178 K183 D187 N188 C192 H298 H350 S358 Q362 3.13.2.1 0004013,0005515,0005634,0005737,0005783,0005829,0006730,0016787,0033353,0042470,0070062 P23526 28533090 501 KLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY 5w49 B 2.4 BS01 NAD A 1 K426 Y430 K423 Y427 H55 S78 S83 D131 E156 N181 K186 D190 N191 C195 H301 H353 S361 Q365 H52 S75 S80 D128 E153 N178 K183 D187 N188 C192 H298 H350 S358 Q362 3.13.2.1 0004013,0005515,0005634,0005737,0005783,0005829,0006730,0016787,0033353,0042470,0070062 P23526 28533090 501 KLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY