5ot3 A 2.04 BS01 peptide D 0 E127 F129 R133 E170 L198 G200 P202 E203 E230 Y235 F239 I246 E116 F118 R122 E159 L187 G189 P191 E192 E219 Y224 F228 I235 D166 K168 N171 D184 T201 D155 K157 N160 D173 T190 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 8 ~ 25 QESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 5ot3 A 2.04 BS02 9LQ A 1 G52 G55 V57 A70 K72 M120 Y122 V123 L173 T183 D184 F327 G41 G44 V46 A59 K61 M109 Y111 V112 L162 T172 D173 F316 D166 K168 N171 D184 T201 D155 K157 N160 D173 T190 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 -logKd/Ki=5.23, Kd=5.86uM P25321 401 QESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF