5os3 A 1.81 BS01 ADP A 1 G140 G142 G145 V147 A160 K162 A213 T217 E260 L263 D274 G14 G16 G19 V21 A34 K36 A87 T91 E134 L137 D148 D256 K258 E260 N261 D274 T292 D130 K132 E134 N135 D148 T166 2.7.11.1 0004672,0005524,0006468 O14965 29045126 401 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS 5os3 A 1.81 BS02 MG A 1 N261 D274 N135 D148 D256 K258 E260 N261 D274 T292 D130 K132 E134 N135 D148 T166 2.7.11.1 0004672,0005524,0006468 O14965 29045126 402 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS 5os3 A 1.81 BS03 A7N A 1 L178 R179 Y199 L52 R53 Y73 D256 K258 E260 N261 D274 T292 D130 K132 E134 N135 D148 T166 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=2.43, Kd=3753uM O14965 29045126 404 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS