5lwn A 1.6 BS01 PHU A 1 W1011 R1059 L1060 W1078 W198 R246 L247 W265 A949 A951 R953 N954 D967 A136 A138 R140 N141 D154 2.7.10.2 0004672,0005524,0006468 P52333 27840070 1201 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 5lwn A 1.6 BS02 79R A 1 L828 A853 E903 Y904 L905 C909 R911 R953 L956 L15 A40 E90 Y91 L92 C96 R98 R140 L143 A949 A951 R953 N954 D967 A136 A138 R140 N141 D154 2.7.10.2 0004672,0005524,0006468 ic50=17nM -logKd/Ki=7.77, IC50=17nM P52333 27840070 1208 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 5lwn A 1.6 BS03 79S A 1 A853 E903 Y904 L905 C909 R911 D912 R953 L956 A40 E90 Y91 L92 C96 R98 D99 R140 L143 A949 A951 R953 N954 D967 A136 A138 R140 N141 D154 2.7.10.2 0004672,0005524,0006468 P52333 27840070 1209 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR