5kjm A 2.19 BS01 SAM A 1 K17 R19 E135 H137 C181 N182 A203 N206 H207 Y240 Y258 F260 K13 R15 E131 H133 C177 N178 A199 N202 H203 Y236 Y254 F256 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005654,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016278,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140938,0140999,1901796 Q9NRG4 28002961 501 GLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH 5kjm A 2.19 BS02 6TM A 1 K145 I149 N180 N182 G183 F184 T185 Y240 Y258 K141 I145 N176 N178 G179 F180 T181 Y236 Y254 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005654,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016278,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140938,0140999,1901796 ic50=0.065uM -logKd/Ki=7.19, IC50=0.065uM Q9NRG4 28002961 502 GLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH 5kjm A 2.19 BS03 ZN A 1 C52 C74 C78 C48 C70 C74 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005654,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016278,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140938,0140999,1901796 Q9NRG4 28002961 503 GLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH 5kjm A 2.19 BS04 ZN A 2 C65 C68 H86 C90 C61 C64 H82 C86 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005654,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016278,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140938,0140999,1901796 Q9NRG4 28002961 504 GLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH 5kjm A 2.19 BS05 ZN A 3 C209 C262 C264 C267 C205 C258 C260 C263 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005654,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016278,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140938,0140999,1901796 Q9NRG4 28002961 505 GLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH