5kcv A 2.7 BS01 6S1 A 1 N53 Q79 W80 L210 T211 V270 Y272 D274 I290 D292 N40 Q66 W67 L141 T142 V201 Y203 D205 I221 D223 D274 K276 N279 D292 D205 K207 N210 D223 2.7.11.1 0001649,0001893,0001934,0001938,0002042,0003376,0004672,0004674,0004712,0005515,0005516,0005524,0005547,0005634,0005654,0005737,0005739,0005758,0005819,0005829,0005886,0005911,0005938,0005977,0005978,0005979,0006006,0006338,0006417,0006468,0006469,0006606,0006809,0006915,0006924,0006954,0006979,0007165,0007173,0007186,0007281,0007399,0008283,0008286,0008637,0009408,0009725,0010467,0010507,0010595,0010628,0010629,0010748,0010761,0010763,0010765,0010907,0010951,0010975,0015630,0016020,0016242,0016301,0016310,0016567,0018105,0018107,0019049,0019221,0019899,0019901,0022605,0030027,0030154,0030163,0030235,0030291,0030307,0030334,0030335,0031295,0031397,0031641,0031663,0031929,0031982,0031999,0032079,0032091,0032094,0032287,0032436,0032869,0032880,0032991,0033138,0034405,0035556,0035655,0035924,0036064,0036294,0042593,0042802,0042803,0042981,0043066,0043154,0043161,0043276,0043325,0043488,0043491,0043536,0044024,0045429,0045600,0045725,0045737,0045746,0045861,0045944,0046326,0046622,0046777,0046889,0048009,0048266,0048661,0051000,0051091,0051146,0051247,0060079,0060416,0060644,0060709,0060716,0070141,0070848,0071356,0071363,0071364,0071380,0071889,0071901,0072655,0072656,0072752,0090201,0097011,0097194,0098794,0098978,0099104,0099175,0106310,0110002,0140052,0150033,0160049,1900087,1900182,1901653,1901796,1902018,1902176,1903038,1903078,1903318,1904263,1905552,1990090,1990418,2000010,2000074,2000402,2001240,2001243 -logKd/Ki=8.30, IC50=5nM P31749 27305487 501 IVKEGWLHKRGEYITWRPRYFLLKNDGTFIGYKERPAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF