5i4o A 2.05 BS01 V28 A 1 G179 I180 A182 L214 T215 H218 Q219 H222 H228 V235 F237 P238 Y240 G72 I73 A75 L107 T108 H111 Q112 H115 H121 V128 F130 P131 Y133 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.28, IC50=53nM P39900 27356908 301 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o A 2.05 BS02 ZN A 1 H218 H222 H228 H111 H115 H121 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o A 2.05 BS03 ZN A 2 H168 D170 H183 H196 H61 D63 H76 H89 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o A 2.05 BS04 CA A 1 D158 G190 G192 D194 D51 G83 G85 D87 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o A 2.05 BS05 CA A 2 D124 E199 E201 D17 E92 E94 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o A 2.05 BS06 CA A 3 D175 G176 G178 I180 D198 E201 D68 G69 G71 I73 D91 E94 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i4o C 2.05 BS01 V28 A 1 E128 R135 E21 R28 H218 Q219 H222 H228 H111 Q112 H115 H121 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 VWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG