5he1 A 3.15 BS01 ZS2 A 1 G198 R199 G200 F202 G203 A218 L235 M274 A321 L324 S334 D335 G170 R171 G172 F174 G175 A190 L207 M246 A293 L296 S306 D307 D317 K319 N322 D335 K344 T353 D289 K291 N294 D307 K316 T325 2.7.11.15 0001664,0002026,0002029,0003108,0004672,0004674,0004703,0005515,0005524,0005737,0005829,0005886,0005929,0006468,0007165,0007186,0007213,0007217,0007507,0016020,0016310,0018105,0019079,0031623,0031694,0031755,0032473,0033605,0042995,0045202,0045988,0046718,0047696,0060048,0098793,0098794,1901081 -logKd/Ki=6.55, IC50=0.28uM IC50=2600nM P25098 27050625 701 SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKP 5he1 A 3.15 BS02 MG A 1 H348 E360 V361 Q363 V366 Y368 H320 E332 V333 Q335 V338 Y340 D317 K319 N322 D335 K344 T353 D289 K291 N294 D307 K316 T325 2.7.11.15 0001664,0002026,0002029,0003108,0004672,0004674,0004703,0005515,0005524,0005737,0005829,0005886,0005929,0006468,0007165,0007186,0007213,0007217,0007507,0016020,0016310,0018105,0019079,0031623,0031694,0031755,0032473,0033605,0042995,0045202,0045988,0046718,0047696,0060048,0098793,0098794,1901081 P25098 27050625 702 SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKP