5am2 A 1.7 BS01 KUF A 1 F267 Y383 F387 L408 L428 F261 Y377 F381 L402 L418 F267 H334 D335 W336 N359 N378 Y383 Y466 D496 H524 F261 H328 D329 W330 N353 N372 Y377 Y456 D486 H514 3.1.3.76,3.3.2.10 0000287,0003824,0004301,0005737,0005777,0005782,0005829,0006629,0009056,0009636,0010628,0015643,0016311,0016787,0016791,0033885,0042577,0042632,0042803,0046272,0046839,0046872,0052642,0070062,0090181,0097176 ic50=9.685uM -logKd/Ki=5.01, IC50=9.685uM P34913 25931264 1552 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR 5am2 A 1.7 BS02 KUF A 2 D496 F497 V498 H524 W525 D486 F487 V488 H514 W515 F267 H334 D335 W336 N359 N378 Y383 Y466 D496 H524 F261 H328 D329 W330 N353 N372 Y377 Y456 D486 H514 3.1.3.76,3.3.2.10 0000287,0003824,0004301,0005737,0005777,0005782,0005829,0006629,0009056,0009636,0010628,0015643,0016311,0016787,0016791,0033885,0042577,0042632,0042803,0046272,0046839,0046872,0052642,0070062,0090181,0097176 ic50=9.685uM -logKd/Ki=5.01, IC50=9.685uM P34913 25931264 1553 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR 5am2 A 1.7 BS03 KUF A 3 W336 M339 Y343 M469 N472 W330 M333 Y337 M459 N462 F267 H334 D335 W336 N359 N378 Y383 Y466 D496 H524 F261 H328 D329 W330 N353 N372 Y377 Y456 D486 H514 3.1.3.76,3.3.2.10 0000287,0003824,0004301,0005737,0005777,0005782,0005829,0006629,0009056,0009636,0010628,0015643,0016311,0016787,0016791,0033885,0042577,0042632,0042803,0046272,0046839,0046872,0052642,0070062,0090181,0097176 ic50=9.685uM -logKd/Ki=5.01, IC50=9.685uM P34913 25931264 1554 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR 5am2 A 1.7 BS04 KUF A 4 I363 S374 I357 S368 F267 H334 D335 W336 N359 N378 Y383 Y466 D496 H524 F261 H328 D329 W330 N353 N372 Y377 Y456 D486 H514 3.1.3.76,3.3.2.10 0000287,0003824,0004301,0005737,0005777,0005782,0005829,0006629,0009056,0009636,0010628,0015643,0016311,0016787,0016791,0033885,0042577,0042632,0042803,0046272,0046839,0046872,0052642,0070062,0090181,0097176 ic50=9.685uM -logKd/Ki=5.01, IC50=9.685uM P34913 25931264 1555 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR