5ak0 A 2.03 BS01 PHS A 1 R252 H253 H387 Q388 R249 H250 H384 Q385 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1446 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ak0 A 2.03 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G262 E319 Y330 R344 K348 Y359 Q385 R389 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1449 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ak0 A 2.03 BS03 8V1 A 1 R45 Y49 I50 S152 S162 I164 V217 G218 F221 L238 M239 I241 R42 Y46 I47 S149 S159 I161 V214 G215 F218 L235 M236 I238 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 ic50=0.021uM -logKd/Ki=7.68, IC50=0.021uM IC50=21nM Q16875 25849762 1450 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS