5ajz A 2.35 BS01 PHS A 1 R252 H253 N259 H387 Q388 R247 H248 N254 H382 Q383 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1446 LELTQSRVQKIWVPVDHRPSLPRSCGNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ajz A 2.35 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G260 E317 Y328 R342 K346 Y357 Q383 R387 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1447 LELTQSRVQKIWVPVDHRPSLPRSCGNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ajz A 2.35 BS03 MJP A 1 R45 G46 Y49 I50 V159 N163 V217 G218 L238 I241 V243 R40 G41 Y44 I45 V154 N158 V212 G213 L233 I236 V238 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 ic50=2.01uM -logKd/Ki=5.70, IC50=2.01uM IC50=2010nM Q16875 25849762 1449 LELTQSRVQKIWVPVDHRPSLPRSCGNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS