4wke A 1.62 BS01 ZN A 1 H361 H365 H371 H142 H146 H152 3.4.24.82 0004222,0006508,0008237 O75173 25415648 501 LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wke A 1.62 BS02 CA A 1 E221 D304 D311 C423 D426 E6 D85 D92 C202 D205 3.4.24.82 0004222,0006508,0008237 O75173 25415648 502 LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wke A 1.62 BS03 CA A 2 E221 D304 D426 E6 D85 D205 3.4.24.82 0004222,0006508,0008237 O75173 25415648 503 LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wke A 1.62 BS04 CA A 3 D320 L321 C327 T329 E349 D101 L102 C108 T110 E130 3.4.24.82 0004222,0006508,0008237 O75173 25415648 504 LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wke A 1.62 BS05 3PU A 1 T329 L330 G331 M332 H361 E362 H371 V390 A392 P393 V394 M395 T110 L111 G112 M113 H142 E143 H152 V169 A171 P172 V173 M174 3.4.24.82 0004222,0006508,0008237 ic50=8nM -logKd/Ki=8.10, Kd=8nM IC50=8.0nM O75173 25415648 508 LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP