4qfr A 3.34 BS01 STU A 1 L22 G23 G25 V30 A43 K45 I77 E94 Y95 V96 G99 E100 E143 L146 A156 D157 L14 G15 G17 V22 A35 K37 I69 E86 Y87 V88 G91 E92 E135 L138 A148 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 P54645 25066137 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qfr A 3.34 BS02 32J A 1 G19 K29 K31 I46 K51 D88 F90 G11 K21 K23 I38 K43 D80 F82 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 -logKd/Ki=8.13, Kd=7.4nM P54645 25066137 606 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qfr B 3.34 BS01 32J A 1 R83 R107 D108 V113 R5 R29 D30 V35 ? -logKd/Ki=8.13, Kd=7.4nM P80386 25066137 606 PTVFRWTGGGKEVYLSGSFNNWSKLPLTRDQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKAPPILPPHLLQVILNKSCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI