4pg3 A 2.696 BS01 LYS A 1 A306 E308 R330 E346 Y348 N503 Y505 E507 G552 G554 A225 E227 R249 E265 Y267 N422 Y424 E426 G455 G457 R330 E332 T337 H338 E500 N503 R559 R249 E251 T256 H257 E419 N422 R462 6.1.1.6 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 Q8IDJ8 24935905 601 PRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLTEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFDSNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRP 4pg3 A 2.696 BS02 KRS A 1 E332 H338 N339 F342 E500 V501 N503 G554 G556 R559 E251 H257 N258 F261 E419 V420 N422 G457 G459 R462 R330 E332 T337 H338 E500 N503 R559 R249 E251 T256 H257 E419 N422 R462 6.1.1.6 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 -logKd/Ki=7.85, Kd=14nM IC50=120nM Q8IDJ8 24935905 602 PRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLTEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFDSNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRP