4obq A 2.19 BS01 MG A 1 S77 H79 I82 T84 S52 H54 I57 T59 D153 K155 Q157 N158 D171 T191 D128 K130 Q132 N133 D146 T155 2.7.11.1 0004672,0005524,0006468 O95819 24673130 402 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK 4obq A 2.19 BS02 2QT A 1 Y36 V39 A52 K54 M105 F107 C108 L160 V170 D171 Y21 V24 A37 K39 M80 F82 C83 L135 V145 D146 D153 K155 Q157 N158 D171 T191 D128 K130 Q132 N133 D146 T155 2.7.11.1 0004672,0005524,0006468 ic50=0.065uM -logKd/Ki=7.19, IC50=65nM IC50=58.6nM O95819 24673130 403 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK