4obp A 2.27 BS01 MG A 1 S77 H79 I82 T84 S65 H67 I70 T72 D153 K155 Q157 N158 D171 T191 D137 K139 Q141 N142 D155 T166 2.7.11.1 0004672,0005524,0006468 O95819 24673130 401 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSANTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTR 4obp A 2.27 BS02 2QU A 1 Y36 V39 A52 K54 M105 F107 C108 L160 D171 Y24 V27 A40 K42 M89 F91 C92 L144 D155 D153 K155 Q157 N158 D171 T191 D137 K139 Q141 N142 D155 T166 2.7.11.1 0004672,0005524,0006468 ic50=0.017uM -logKd/Ki=7.77, IC50=17nM IC50=11.5nM O95819 24673130 403 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSANTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTR