4o0v A 2.8 BS01 2OL A 1 I327 V335 K350 E366 V379 M395 L398 G401 L447 S457 D458 F459 I29 V37 K52 E68 V81 M97 L100 G103 L149 S159 D160 F161 D440 K442 D444 S445 D458 K467 T478 D142 K144 D146 S147 D160 K169 T180 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.48, Ki=3.3nM IC50=4.8nM, Ki=3.3nM O96013 24432870 601 GSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR