4ktc A 2.3 BS01 peptide B 0 P2 I3 T4 A5 Y6 S7 Q8 T10 R11 T19 S20 D30 V33 V35 L36 S37 K62 T63 L64 A65 P2 I3 T4 A5 Y6 S7 Q8 T10 R11 T19 S20 D30 V33 V35 L36 S37 K62 T63 L64 A65 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26662 23672640 221 ~ 233 APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESM 4ktc A 2.3 BS02 ZN A 1 C99 C145 C99 C145 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26662 23672640 201 APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESM 4ktc A 2.3 BS03 1X3 A 1 Q41 F43 H57 D81 V132 L135 K136 G137 S139 F154 R155 A156 A157 D168 Q41 F43 H57 D81 V132 L135 K136 G137 S139 F154 R155 A156 A157 D168 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 ic50=1nM -logKd/Ki=9.00, IC50=1nM P26662 23672640 202 APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESM 4ktc C 2.3 BS02 1X3 A 1 N49 V51 M74 Y75 P86 N49 V51 M74 Y75 P86 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 ic50=1nM P26662 23672640 202 APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTM