4gr3 A 1.494 BS01 ZN A 1 H218 H222 H228 H114 H118 H124 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 23343195 301 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 4gr3 A 1.494 BS02 ZN A 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 23343195 302 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 4gr3 A 1.494 BS03 CA A 1 D158 G190 G192 D194 D54 G86 G88 D90 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 23343195 303 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 4gr3 A 1.494 BS04 CA A 2 D124 E199 E201 D20 E95 E97 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 23343195 304 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 4gr3 A 1.494 BS05 CA A 3 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 23343195 305 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 4gr3 A 1.494 BS06 R45 A 1 H172 G179 I180 L181 A182 H183 T215 H218 E219 H222 H228 V235 F237 T239 Y240 H68 G75 I76 L77 A78 H79 T111 H114 E115 H118 H124 V131 F133 T135 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=15.5nM -logKd/Ki=7.81, Ki=15.5nM Ki=16nM P39900 23343195 306 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG