4ejn A 2.19 BS01 0R4 A 1 N53 N54 Q59 Q79 W80 I84 L210 T211 V270 Y272 R273 I290 D292 N43 N44 Q49 Q69 W70 I74 L153 T154 V213 Y215 R216 I233 D235 D274 K276 N279 D292 T312 D217 K219 N222 D235 T250 2.7.11.1 0001649,0001893,0001934,0001938,0002042,0003376,0004672,0004674,0004712,0005515,0005516,0005524,0005547,0005634,0005654,0005737,0005739,0005758,0005819,0005829,0005886,0005911,0005938,0005977,0005978,0005979,0006006,0006338,0006417,0006468,0006469,0006606,0006809,0006915,0006924,0006954,0006979,0007165,0007173,0007186,0007281,0007399,0008283,0008286,0008637,0009408,0009725,0010467,0010507,0010595,0010628,0010629,0010748,0010761,0010763,0010765,0010907,0010951,0010975,0015630,0016020,0016242,0016301,0016310,0016567,0018105,0018107,0019049,0019221,0019899,0019901,0022605,0030027,0030154,0030163,0030235,0030291,0030307,0030334,0030335,0031295,0031397,0031641,0031663,0031929,0031982,0031999,0032079,0032091,0032094,0032287,0032436,0032869,0032880,0032991,0033138,0034405,0035556,0035655,0035924,0036064,0036294,0042593,0042802,0042803,0042981,0043066,0043154,0043161,0043276,0043325,0043488,0043491,0043536,0044024,0045429,0045600,0045725,0045737,0045746,0045861,0045944,0046326,0046622,0046777,0046889,0048009,0048266,0048661,0051000,0051091,0051146,0051247,0060079,0060416,0060644,0060709,0060716,0070141,0070848,0071356,0071363,0071364,0071380,0071889,0071901,0072655,0072656,0072752,0090201,0097011,0097194,0098794,0098978,0099104,0099175,0106310,0110002,0140052,0150033,0160049,1900087,1900182,1901653,1901796,1902018,1902176,1903038,1903078,1903318,1904263,1905552,1990090,1990418,2000010,2000074,2000402,2001240,2001243 ic50=0.005uM -logKd/Ki=8.30, IC50=5nM IC50=44nM P31749 22533986 501 VAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF