4dwb A 2.1 BS01 IPE A 1 G47 K48 F50 R51 Q91 G47 K48 F50 R51 Q91 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 22715997 501 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK 4dwb A 2.1 BS02 MG A 1 D98 D102 D98 D102 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 22715997 506 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK 4dwb A 2.1 BS03 MG A 2 D98 D102 D98 D102 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 22715997 507 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK 4dwb A 2.1 BS04 0M7 A 1 Y94 D98 R107 T163 Q167 K207 Y211 D250 K264 Y94 D98 R107 T163 Q167 K207 Y211 D250 K264 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=1840nM -logKd/Ki=5.74, IC50=1840nM Q95WL3 22715997 509 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK