4ark A 2.6 BS01 ADP A 1 G77 V82 A95 K97 M143 M146 S150 Q153 S194 L197 G17 V22 A35 K37 M83 M86 S90 Q93 S134 L137 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 23474388 1383 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4ark A 2.6 BS02 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 23474388 1384 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4ark A 2.6 BS03 M3K A 1 K97 V127 M143 D190 D208 F209 V211 L215 M219 K37 V67 M83 D130 D148 F149 V151 L155 M159 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=7.20, IC50=63nM Q02750 23474388 1385 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN